San Francisco 49ers face a daunting Week 17 test against Detroit Lions with injuries threatening their ability to compete.

The 49ers are eliminated from the playoffs. But don't tell Kittle or Samuel that, with both studs having two of their best ...

The Detroit Lions and San Francisco 49ers met 11 months ago at Levi's Stadium with a trip to the Super Bowl on the line. San Francisco used a furious second half comeback to steal the NFC Championship ...

The Detroit Lions visit the San Francisco 49ers on Monday at 8:15 p.m. ET, in a matchup featuring a pair of the best ...

For Lions defensive coordinator Aaron Glenn's money, 49ers star George Kittle is the best tight end in football.

Detroit Lions defensive coordinator Aaron Glenn called San Francisco 49ers TE George Kittle 'the best tight end in the game.' ...

The Lions will face a 49ers offensive line that could be starting two tackles signed off practice squads this week ...

With the exception of David Montgomery, the Lions had perfect practice attendance Saturday among players on the active roster ...

David Montgomery (knee) is the only player missing from the active roster. The starting running back remains in limbo, with ...

San Francisco 49ers top scorers look to capitalize on opportunities early against Detroit Lions stout defense.

The Lions held a 17-point lead in the NFC championship game over the San Francisco 49ers before getting outscored 27-7 in the ...