To make matters worse, offensive lineman Spencer Burford, who was supposed to start at left tackle with Williams and his backup Jaylon Moore on IR for the season, is listed as ‘out’ on the injury report with a calf injury he sustained in the team’s Week 16 loss to the Miami Dolphins.

In other words, the 49ers’ disappointment is getting worse as the season carries on. San Francisco has already lost stars in Brandon Aiyuk, Christian McCaffrey and Trent Williams for the year, but secondary players like Dre Greenlaw, Isaac Guerendo, Leonard Floyd and Ji’Ayir Brown are also banged up.