Notre Dame and Penn State are set for the College Football Playoff Orange Bowl semifinal with a shot at the national title matchup on the line. Here’s the latest prediction for the game from an expert analytical model that projects scores and picks winners.

Jan 2, 2025; New Orleans, LA, USA; Notre Dame Fighting Irish head coach Marcus Freeman (R) reacts on the sidelines in the final minute against the Georgia Bulldogs during the fourth quarter at Caesars Superdome. Mandatory Credit: Geoff Burke-Imagn Images

Jimmie Kaylor revealed his College Football Playoff semifinal picks for Penn State vs. Notre Dame in the 2025 Orange Bowl on Thursday